Muconate cycloisomerase

Muconate cycloisomerase (MCI) catalyzes the formation of muconolactone from cis, cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds.

3D Structures of muconate cycloisomerase3D Structures of muconate cycloisomerase

Cloro-MCICloro-MCI

2chr – MCI – Cupriavidsua necator
1nu5 - MCI – Pseudomonas

cis, cis-MCIcis, cis-MCI

1muc, 1bkh – PbMCI – Pseudomonas putida
3muc, 2muc, 1f9c – PbMCI (mutant)
3fyy – OiMCI – Oceanobacillus iheyensis
3i4k – MCI – Corynebacterium glutamicum
3i6e – MCI – Ruegeria pomeroyi
3i6t – MCI – Jannaschia
3my9 – MCI – Azorhizobium caulinodans
2zad – TmMCI – Thermotoga maritima
3ct2 - PfMCI – Pseudomonas fluorescens
3dg3 – MsMCI - Mycobacterium smegmatis

cis, cis-MCI complexescis, cis-MCI complexes

3es7, 3es8 – OiMCI + Mg + malate
3gd6 – OiMCI + phosphate
3hpf – OiMCI (mutant) + Mg + galactarate
3dg6, 3dg7 – MsMCI + muconolactone
3dgb, 3fj4 - PfMCI + muconolactone

3-carboxy-cis, cis-MCI3-carboxy-cis, cis-MCI

1q5n – MCI – Acinetobacter calcoaceticus
1re5 - PbMCI

Dipeptide epimeraseDipeptide epimerase

3iji, 3ijl, 3ijq– MCI + dipeptide – Bacterioides thetaiotaomicron
3deq, 3der, 3des – TmMCI + dipeptide
3dfy – TmMCI
3q45, 3q4d – MCI + Mg + dipeptide – Cytophaga hutchinsonii
3rit - MCI + Mg + dipeptide – Methylococcus capsulatus