Macrophage inhibitory factor

Macrophage inhibitory factor (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens. MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60.

3D structures of macrophage inhibitory factor3D structures of macrophage inhibitory factor

Updated on 24-March-2014

1mif – MIF (mutant) – rat
1fim, 1gif, 1gd0, 3djh – hMIF – human
1cgq, 1p1g, 4etg, 4eui, 4evg, 4grn, 4gro, 4grp, 4grq, 4grr, 4gru – hMIF (mutant)
1mff – mMIF (mutant) – mouse
1hfo – MIF – Trichinella spiralis
1uiz – MIF – Xenopus laevis
2wkb, 2wkf – MIF – Plasmodium berghei
3t5s – MIF – Giardia lamblia
4gum – MIF (mutant) – rhesus monkey

MIF complexesMIF complexes

1mfi, 2gdg – mMIF + inhibitor
1ca7 – hMIF + hydroxyphenylpyruvate
3ijj – hMIF + hydroxyphenylpyruvate + inhibitor
1gcz, 1ljt, 2ooh, 2oow, 2ooz, 3b9s, 3jsf, 3jsg, 3jtu, 3l5p, 3l5r, 3l5s, 3l5t, 3l5u, 3l5v, 3ijg, 4f2k, 3smb, 3smc, 3wnr, 3wns. 3wnt, 4osf, 4p01 – hMIF + inhibitor
3dji – hMIF + tylenol
3ce4 – hMIF + PMSF
3hof – hMIF + cafeic acid
3u18 – hMIF + Chicago sky blue
3rf4, 3rf5 – MIF + inhibitor – Ancylostoma ceylanicum

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky