Interleukin

Template:STRUCTURE 2nvh

Interleukin (IL) is a cytokine which functions in the immune system. IL deficiency results in autoimmune disease. IL families are denoted by numbers.

• IL-1 is a group of 11 cytokines which regulate immune and inflammatory response. See Interleukin-1 beta.
  
• IL-2 is a cytokine made by leukocytes. It is used in cancer therapy to boost the immune system.
  
• IL-3 improves the body's natural response to disease by stimulating the differentiation of multipotent hematopoietic stem cells into myeloid or lymphoid progenitor cells.
  
• IL-4 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  
• IL-5 stimulates B cell growth and increases immunoglobulin secretion.
  
• IL-6 is both a pro-inflammatory cytokine and anti-inflammatory myokine.
  
• IL-7 is a cytokine important for B and T cells development.
  
• IL-8 induces chemotaxis and phagocytosis.
  
• IL-10 see Interleukin-10.
  
• IL-12 induces the differentiation of naive helper T cells (Th0) to Th1 cells.
  
• IL-13 induces the differentiation of naive helper T cells (Th0) to Th2 cells.
  
• IL-15 see Interleukin-15.
  
• IL-16 acts as chemoattractant, modulator of T cell activity and inhibitor of HIV replication.
  
• IL-17 recruits monocytes and neutrophils to the site of inflammation.
  
• IL-18 induces cell-mediated immunity following infection by microbial lipopolysaccharides.
  
• IL-19 induces activation of the signal transducer and activator of STAT3.
  
• IL-21 has potent effect on natural killer cells.
  
• IL-22 stimulates inflammatory responses like S100 and defensin.
  
• IL-23 induces activation of the signal transducer and activator of STAT4.
  
• IL-28 has a role in the immune defense against viruses.
  
• IL-29 similar to IL-28.
  
• IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines.
  
• IL-34 increases growth or survival of monocytes.
  

3D structures of interleukin3D structures of interleukin

Updated on 25-February-2014

IL-1 αIL-1 α

2ila - hIL-1 α - human
2kki - hIL-1 α residues 121-271
2l5x – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR

IL-1 βIL-1 β

2wry - cIL-1 β – chicken
3nj5 – cIL-1 β (mutant)
2nvh, 9ilb, 1iob, 5i1b, 2i1b, 4i1b, 1i1b - hIL-1 β 1tp0, 1t4q, 1too, 1twe, 1twm, 1s0l, 1l2h, 1hib, 21bi, 31bi, 41bi - hIL-1 β (mutant)
6i1b, 7i1b - hIL-1 β - NMR
3ltq - hIL-1 β residues 117-269
3pok - hIL-1 β residues 117-269 (mutant)
1itb - hIL-1 β + IL-1 receptor 1 extracellular domain
3o4o - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein
4g6j, 4g6m - hIL-1 β + antibody
2kh2 - hIL-1 β + SCFV - NMR
1md6 – mIL-1F5 – mouse
2mib, 8i1b - mIL-1 β

IL-2 (T-cell growth factor)IL-2 (T-cell growth factor)

1m47, 1m4c, 3ink – hIL-2
3qb1 - hIL-2 (mutant)
1irl – hIL-2 (mutant) - NMR
2erj, 2b5i - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ
1z92 - hIL-2 + IL-2 receptor α
1qvn, 1nbp, 1m4a, 1m4b – hIL-2 (mutant) + inhibitor
1pw6, 1py2, 1m48, 1m49 – hIL-2 + inhibitor

IL-3IL-3

1jli – hIL-3 (mutant) – NMR
2l3o – mIL-3 residues 33-156 (mutant) - NMR

IL-4IL-4

2b8u, 1hik, 2int, 1rcb – hIL-4
2cyk, 1cyl, 1itm, 1bbn, 1bcn, 1iti, 1itl – hIL-4 - NMR
2b8x, 2b8y, 2b8z, 2b90, 2b91, 2d48, 1hzi, 1hij - hIL-4 (mutant)
1iar - hIL-4 + IL-4 receptor α (mutant)
3bpl - hIL-4 + IL-4 receptor α + cytokine receptor common γ
3bpn - hIL-4 + IL-4 receptor α + IL-13 receptor α

IL-5IL-5

1hul – hIL-5
3b5k – mIL-5

IL-6IL-6

1alu – hIL-6
2l3y - mIL-6 residues 27-211 - NMR
1il6, 2il6 – hIL-6 - NMR
1p9m - hIL-6 + IL-6 receptor α and β
1i16 – IL-6 + IL-6 receptor β - Herpesvirus 8

IL-7IL-7

3di2, 3di3 - hIL-7 residues 26-177 + IL-7 receptor α ectodomain

IL-8IL-8

3il8 – hIL-8
1il8, 2il8 – hIL-8]- NMR
1qe6, 1icw – hIL-8 (mutant)
1ikl, 1ikm - hIL-8 (mutant) - NMR
1rod - hIL-8/melanoma growth stimulating protein – NMR
1ilp, 1ilq - hIL-8 + IL-8 receptor peptide

IL-10IL-10

2h24, 1inr, 2ilk, 1ilk – hIL-10
1j7v – hIL-10 + IL-10 receptor α (mutant)
1y6k - hIL-10 residues 19-178 + IL-10 receptor α

IL-10 viralIL-10 viral

1vlk - hvIL-10 residues 26-170 - human herpesvirus 4
1y6m - hvIL-10 residues 26-170 + IL-10 receptor α
1y6n - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α
1lqs - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5
1lk3 - hvIL-10 residues 26-175 + antibody

IL-12IL-12

1f45 - hIL-12 α and β (mutant)
1f42 - hIL-12 β P40 domain
3hmx - hIL-12 α and β+ antibody
3qwr - hIL-12 β + hIL- 23 α + adnectin

IL-13IL-13

1ijz, 1ik0 – hIL-13 – NMR
1ga3 - hIL-13 residues 21-132 - NMR
3l5w, 3l5x, 3l5y, 3g6d, 4i77 - hIL-13 residues 35-146 + antibody
3lb6 - hIL-13 + IL-13 receptor α2
3bpo - hIL-13 + IL-4 receptor α + IL-13 receptor α

IL-15IL-15

2xqb – hIL-15 + antibody
2psm, 2z3q, 2z3r - hIL-15 + IL-15 receptor α

IL-16IL-16

1i16 – hIL-16 - NMR
1x6d – hIL-16 PDZ domain – NMR

IL-17IL-17

4hr9 - hIL-17A (mutant)
2vxs - hIL-17A residues 20-255 + antibody
1jpy – hIL-17F
3jvf - hIL-17F + IL-17 receptor α

IL-18 (Interferon-γ inducing factor)IL-18 (Interferon-γ inducing factor)

1j0s – hIL-18 - NMR
4hjj - hIL-18 + antibody
2vxt - hIL-18 (mutant) + antibody
3f62 - hIL-18 residues 37-193 (mutant) + IL-18 binding protein
4eee, 4ekx - hIL-18 (mutant) + 14L protein

IL-19IL-19

1n1f – hIL-19

IL-21IL-21

2oqp– hIL-21 – NMR

IL-22IL-22

1ykb, 1m4r – hIL-22
3g9v - hIL-22 residues 29-179 + IL-22 receptor α2
3dlq, 3dgc - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1
3q1s - hIL-22 residues 29-179 (mutant) + antibody

IL-23IL-23

3d87 - hIL-23 α
3d85 - hIL-23 α + antibody
3duh - hIL-23 α + hIL-12 β

IL-28IL-28

3hhc – hIL-28B

IL-29IL-29

3og4, 3og6 – hIL-29 + IL-28 receptor α

IL-33IL-33

2kll - hIL-33 residues 110-270 - NMR

IL-34IL-34

4dkc - hIL-34
4exn - mIL-34
4dkd - hIL-34 active core + macrophage colony-stimulating factor 1 receptor
4exp - mIL-34 active core + macrophage colony-stimulating factor 1 receptor
4dke, 4dkf - hIL-34 active core + antibody