CREB-binding protein

File:1kbh.png

Crystal structure of CREB-binding protein (green) complex with nuclear receptor coactivator (grey) 1kbh

CREB-binding protein (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 interacts with the N-terminal of p73.

3D Structures of CREB-binding protein3D Structures of CREB-binding protein

Updated on 23-February-2014

4i9o – mCBP GACKIX domain (mutant) - mouse
1f81 – mCBP TAZ2 domain - NMR
1u2n – mCBP TAZ1 domain - NMR
1jjs – mCBP IBiD domain - NMR
1liq – mCBP CH1 domain - NMR
1tot – mCBP ZZ domain – NMR
2kkj – mCBP nuclear coactivator binding domain - NMR
1wo3, 1wo4, 1wo5, 1wo6, 1wo7 – hCBP zinc finger domain (mutant) – human - NMR
2d82 – hCBP bromodomain - NMR
3dwy – hCBP bromodomain
3p1c, 3p1d, 3p1e, 3p1f, 3svh, 4a9k – hCBP bromodomain + small molecule
2l84, 2l85 – hCBP bromodomain + small molecule - NMR

CBP complex with proteinCBP complex with protein

1kbh – hCBP + nuclear receptor coactivator - NMR
1zoq – hCBP + interferon regulatory factor 3
2c52 – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR
1r8u – mCBP TAZ1 domain + P300-interacting transactivator - NMR
1l8c – mCBP TAZ1 domain + hypoxia-inducible factor 1α - NMR
2lww - mCBP TAZ1 domain + nuclear transcription factor RELA – NMR
2ka6 – mCBP TAZ2 domain + STAT1-TAD - NMR
2ka4 – mCBP TAZ2 domain + STAT2-TAD - NMR
1kdx – mCBP KIX domain + CREB kinase inducible domain - NMR
2kje – hCBP TAZ2 domain + adenoviral E1A peptide - NMR
1jsp – hCBP bromodomain + p53 peptide - NMR
2l14 – mCBP nuclear coactivator binding domain + p53 peptide - NMR
1sb0 – mCBP KIX domain + protein c-Myb – NMR
2agh – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR
2lqh, 2lqi – mCBP KIX domain + forkhead box O3 – NMR
2kwf – hCBP KIX domain + transcription factor 4 – NMR
2lxs, 2lxt – hCBP KIX domain + histone methyltransferase MLL peptide – NMR
2rny – hCBP bromodomain + histone H3 peptide - NMR
4n3w, 4n4f - hCBP bromodomain + histone H4 peptide
4nr4, 4nr5, 4nr6, 4nr7, 4nyv, 4nyw, 4nyx- hCBP bromodomain + ligand