3wn4
Crystal structure of human TLR8 in complex with DS-877Crystal structure of human TLR8 in complex with DS-877
Template:ABSTRACT PUBMED 24474703
FunctionFunction
[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]
About this StructureAbout this Structure
3wn4 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Kokatla HP, Sil D, Tanji H, Ohto U, Malladi SS, Fox LM, Shimizu T, David SA. Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists. ChemMedChem. 2014 Jan 28. doi: 10.1002/cmdc.201300573. PMID:24474703 doi:http://dx.doi.org/10.1002/cmdc.201300573
- ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200