4nyk
Structure of a membrane proteinStructure of a membrane protein
Template:ABSTRACT PUBMED 19641589
FunctionFunction
[ASIC1_CHICK] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).[1]
About this StructureAbout this Structure
4nyk is a 1 chain structure. This structure supersedes the now removed PDB entry 3hgc. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Gonzales EB, Kawate T, Gouaux E. Pore architecture and ion sites in acid-sensing ion channels and P2X receptors. Nature. 2009 Jul 30;460(7255):599-604. PMID:19641589 doi:10.1038/nature08218
- ↑ Coric T, Zheng D, Gerstein M, Canessa CM. Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel. J Physiol. 2005 Nov 1;568(Pt 3):725-35. Epub 2005 Jul 7. PMID:16002453 doi:http://dx.doi.org/jphysiol.2005.087734