3igq

Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channelCrystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel

Template:ABSTRACT PUBMED 19917292

FunctionFunction

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.^[1]

About this StructureAbout this Structure

3igq is a 6 chain structure with sequence from Glovo. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M. Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel. J Mol Biol. 2010 Feb 5;395(5):1114-27. Epub 2009 Nov 13. PMID:19917292 doi:10.1016/j.jmb.2009.11.024

↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

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OCA

[2] Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M. Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel. J Mol Biol. 2010 Feb 5;395(5):1114-27. Epub 2009 Nov 13. PMID:19917292 doi:10.1016/j.jmb.2009.11.024

[1] Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

[1]

[xtra 1]