4n06
Crystal structure of Cas1 from Archaeoglobus fulgidus and its nucleolytic activityCrystal structure of Cas1 from Archaeoglobus fulgidus and its nucleolytic activity
Template:ABSTRACT PUBMED 24211577
FunctionFunction
[CAS1A_ARCFU] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
About this StructureAbout this Structure
4n06 is a 2 chain structure with sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Kim TY, Shin M, Huynh Thi Yen L, Kim JS. Crystal structure of Cas1 from Archaeoglobus fulgidus and characterization of its nucleolytic activity. Biochem Biophys Res Commun. 2013 Nov 29;441(4):720-5. doi:, 10.1016/j.bbrc.2013.10.122. Epub 2013 Nov 5. PMID:24211577 doi:http://dx.doi.org/10.1016/j.bbrc.2013.10.122