4j2x
CSL (RBP-Jk) with corepressor KyoT2 bound to DNACSL (RBP-Jk) with corepressor KyoT2 bound to DNA
Template:ABSTRACT PUBMED 24290140
FunctionFunction
[SUH_MOUSE] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.[1] [FHL1_MOUSE] May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems.
About this StructureAbout this Structure
4j2x is a 8 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Collins KJ, Yuan Z, Kovall RA. Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling. Structure. 2014 Jan 7;22(1):70-81. doi: 10.1016/j.str.2013.10.010. Epub 2013 Nov , 27. PMID:24290140 doi:http://dx.doi.org/10.1016/j.str.2013.10.010
- ↑ Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A. Signalling downstream of activated mammalian Notch. Nature. 1995 Sep 28;377(6547):355-8. PMID:7566092 doi:http://dx.doi.org/10.1038/377355a0