| This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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The Na+/K+-ATPase is a transmembrane protein which generates an electrochemical gradient for sodium and potassium ions thanks to the hydrolysis of ATP. This pump exchanges three Na+ (in) to two K+ (out) per ATP.
It belongs to the family of P-type ATPase, also known E1-E2 ATPases, which are phosphorylated on an Aspartateresidue during the transport cycle.
It is vital to animal cells, to their volume regulation, to their homeostasis.Moreover, depending on the cells where the pump is, it allows the formation of a membrane potential, the transport of molecules through the membrane thanks to ionic concentration gradients.
These gradients provide energyother secondary active transport.