4j7y
Human LTC4 synthase in complex with product analogs - implications for enzyme catalysisHuman LTC4 synthase in complex with product analogs - implications for enzyme catalysis
DiseaseDisease
[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
FunctionFunction
[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
About this StructureAbout this Structure
4j7y is a 1 chain structure. Full crystallographic information is available from OCA.