4lh6
Crystal structure of a LigA inhibitorCrystal structure of a LigA inhibitor
Template:ABSTRACT PUBMED 24287382
FunctionFunction
[DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
About this StructureAbout this Structure
4lh6 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Murphy-Benenato K, Wang H, McGuire HM, Davis HE, Gao N, Prince DB, Jahic H, Stokes SS, Boriack-Sjodin PA. Identification through structure-based methods of a bacterial NAD-dependent DNA ligase inhibitor that avoids known resistance mutations. Bioorg Med Chem Lett. 2013 Nov 15. pii: S0960-894X(13)01286-9. doi:, 10.1016/j.bmcl.2013.11.007. PMID:24287382 doi:http://dx.doi.org/10.1016/j.bmcl.2013.11.007