4fqw
Crystal Structure of AAAA+UDP+Gal at pH 5.0 with MPD as the cryoprotectantCrystal Structure of AAAA+UDP+Gal at pH 5.0 with MPD as the cryoprotectant
Template:ABSTRACT PUBMED 24265507
FunctionFunction
[BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
About this StructureAbout this Structure
4fqw is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Johal AR, Blackler RJ, Alfaro JA, Schuman B, Borisova S, Evans SV. pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in formation of the semi-closed state. Glycobiology. 2013 Nov 20. PMID:24265507 doi:http://dx.doi.org/10.1093/glycob/cwt098