Stimulator of interferon genes

<StructureSection load='4ef4' size='350' side='right' caption='Structure of human STING CTD complex with c-di-GMP (stick model) and Ca+2 ion (green) (PDB entry 4ef4)' scene=>

Stimulator of interferon genes (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling.

3D structures of STING3D structures of STING

4ef5, 4f5w, 4f9e – hSTING CTD - human
4f5e – hSTING CTD (mutant)
4jc5, 4kc0 – mSTING CTD - mouse

STING complex with ligandSTING complex with ligand

4ef4, 4f5y, 4f9g – hSTING CTD + c-di-GMP
4emt – hSTING residues 155-341 + c-di-GMP
4f5d – hSTING CTD (mutant) + c-di-GMP
4kby – mSTING CTD + c-di-GMP
4ksy – hSTING CTD + cGAMP
4loh, 4loi – hSTING CTD + c-di-GMP derivative
4loj, 4lok – mSTING CTD + c-di-GMP derivative
4lol – mSTING CTD + chemptherapeutic agent DMXAA