4mqs
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxoStructure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo
Template:ABSTRACT PUBMED 24256733
DiseaseDisease
[ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
FunctionFunction
[ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
About this StructureAbout this Structure
4mqs is a 2 chain structure with sequence from Camelus glama and Human. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hubner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Nov 20. doi: 10.1038/nature12735. PMID:24256733 doi:http://dx.doi.org/10.1038/nature12735