RuBisCO

spinqualitylabelsall models PDB ID 1rcx Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Spinach RuBisCO 8 large and 8 small chains complex with substrate ribulose-1,5- bisphosphate, 1rcx
Ligands:
Activity:	Ribulose-bisphosphate carboxylase, with EC number 4.1.1.39
Structural annotation: Resources: CATH : 1Rcxb02, 1Rcxb01, 1Rcxc00, 1Rcxe01, 1Rcxe02, 1Rcxf00, 1Rcxh02, 1Rcxh01, 1Rcxi00, 1Rcxk02, 1Rcxk01, 1Rcxl01, 1Rcxl02, 1Rcxm00, 1Rcxo02, 1Rcxo01, 1Rcxp00, 1Rcxr02, 1Rcxr01, 1Rcxs00, 1Rcxt00, 1Rcxv01, 1Rcxv02, 1Rcxw00 InterPro : Ipr000685, Ipr000894 Pfam : PF00016, PF02788, PF00101 SCOP : d1rcxb2, d1rcxb1, d1rcxc_, d1rcxe2, d1rcxe1, d1rcxf_, d1rcxh2, d1rcxh1, d1rcxi_, d1rcxk2, d1rcxk1, d1rcxl2, d1rcxl1, d1rcxm_, d1rcxo2, d1rcxo1, d1rcxp_, d1rcxr1, d1rcxr2, d1rcxs_, d1rcxt_, d1rcxv2, d1rcxv1, d1rcxw_ UniProt : P00875, P00870
Functional annotation: Cellular component: chloroplast chloroplast ribulose bisphosphate carboxylase complex Biological process: carbon utilization by fixation of carbon dioxide photosynthesis photorespiration reductive pentose-phosphate cycle Molecular function: lyase activity magnesium ion binding metal ion binding ribulose-bisphosphate carboxylase activity monooxygenase activity oxidoreductase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Ribulose-1,5-bisphosphate carboxylase oxygenase – RuBisCO (RBCO) catalyzes the first step in carbon fixation. RBCD carboxylates or oxygenates ribulose-1,5-bisphosphate with CO2 or O2. RBCD usually consists of a large chain (LSMT – large subunit methyltrasferase) and small chain. 2-carboxylarabinitol-1,5-bisphosphate (2-CABP) is an inhibitor of RCBD. Some additional details in Ribulose-1,5-bisphosphate carboxylase/oxygenase.

Quaternery StructureQuaternery Structure

The Rubisco is shown in spacefill with its 8 large subunits in shades of blue and and its 8 small subunits in shades of yellow. The large subunits arranged in head-to-toe pairs like staves in a barrel and the small subunits are arranged at the ends of the barrel. The function of the small subunits is not understood. Each has located in their interface (shown here with bound RUBP in CPK spacefill).

3D Structures of RuBisCO3D Structures of RuBisCO

Updated February 2013

RuBisCORuBisCO

3rg6, 1rbl – SeRBCO – Synechococcus elongatus
2ybv - RBCO – Thermosynechococcus elongatus
3qfw - RBCO large subunit – Rhodopseudomonas palustris
1uzh, 1gk8 – CrRBCO – Chlamydomonas reinhardtii
1uw9, 1uwa – CrRBCO (mutant)
1svd – RBCD – Halothiobacillus neapolitanus
1bxn – RBCO – Cupriavidus necator
1aus - spRBCO – spinach
1rba - RrRBCO (mutant) – Rhododpirillum rubrum
5rub - RrRBCO
2wvw – RBCO – Anabena – Cryo EM
2vdh, 2vdi, 2v67, 2v68, 2v63, 2v69, 2v6a - CrRBCO (mutant)
1mlv - pRBCO LSMT – pea
2cxe, 2cwx – PhRBCO - Pyrococcus horikoshii
1uzd – CrRBCO/spRBCO
1geh – TkRBCO – Thermococcus kodakaraensis
1iwa - GpRBCO – Galdieria partita
1tel – RBCO large subunit – Chlorobium tepidum
1rld, 3rub, 3t15, 3zw6, 4rub – tRBCO – tobacco
3thg – RBCO – creosote bush
4hhh – RBCO - pea

RuBisCO complex with inhibitor 2-CABPRuBisCO complex with inhibitor 2-CABP

3kdn, 3a12 – TkRBCO III + 2-CABP
3kdo, 3a13 - TkRBCO III (mutant) + 2-CABP
1ir2 - CrRBCO + 2-CABP
1upm, 1upp, 1rbo, 3ruc, 8ruc - spRBCO + 2-CABP + cation
1ir1 - spRBCO + 2-CABP + CO2 + Mg
1wdd – rRBCO + 2-CABP – rice
1bwv - GpRBCO + 2-CABP
1rlc - tRBCO + 2-CABP

RuBisCO complex with productRuBisCO complex with product

1aa1 – spRBCO + phosphoglycerate
1rus - RrRBCO + phosphoglycerate

RuBisCO complex with substrateRuBisCO complex with substrate

1rcx, 1rxo – spRBCO + ribulose-1,5-bisphosphate
9rub - RrRBCO + ribulose-1,5-bisphosphate
1rsc - SeRBCO + xylulose-1,5-bisphosphate
1rco - spRBCO + xylulose-diol-1,5-bisphosphate
3zxw - SeRBCO + carboxyarabinitol-1,5-bisphosphate

RuBisCO complexesRuBisCO complexes

2h21 – pRBCO LSMT + AdoMet
2h23 - pRBCO LSMT + AdoHcy
2h2e, 1ozv, 1p0y - pRBCO LSMT + AdoMet + lysine
2h2j - pRBCO LSMT + sinefungin
2d69 – PhRBCO + sulfate
2rus - RrRBCO + CO2 + Mg
4f0h – GsRBCO + O2 – Galdieria sulphuraria
4f0k - GsRBCO + CO2 + Mg
4f0m - GsRBCO + Mg
1ej7 – tRBCO + phosphate
3axk – rRBCO + NADP
3axm – rRBCO + 6PG