4c85

zebrafish ZNRF3 ectodomain crystal form IIzebrafish ZNRF3 ectodomain crystal form II

FunctionFunction

[ZNRF3_DANRE] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components.

About this StructureAbout this Structure

4c85 is a 2 chain structure with sequence from Brachidanio rerio. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776 doi:http://dx.doi.org/10.1038/ncomms3787

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OCA

[1] Zebisch M, Xu Y, Krastev C, Macdonald BT, Chen M, Gilbert RJ, He X, Jones EY. Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin. Nat Commun. 2013 Nov 14;4:2787. doi: 10.1038/ncomms3787. PMID:24225776 doi:http://dx.doi.org/10.1038/ncomms3787

[xtra 1]