4n5t
The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041The 1.7A Crystal Structure of MDMX with a Stapled Peptide, ATSP-7041
Template:ABSTRACT PUBMED 23946421
FunctionFunction
[MDM4_DANRE] Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity).
About this StructureAbout this Structure
4n5t is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Chang YS, Graves B, Guerlavais V, Tovar C, Packman K, To KH, Olson KA, Kesavan K, Gangurde P, Mukherjee A, Baker T, Darlak K, Elkin C, Filipovic Z, Qureshi FZ, Cai H, Berry P, Feyfant E, Shi XE, Horstick J, Annis DA, Manning AM, Fotouhi N, Nash H, Vassilev LT, Sawyer TK. Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3445-54. doi:, 10.1073/pnas.1303002110. Epub 2013 Aug 14. PMID:23946421 doi:http://dx.doi.org/10.1073/pnas.1303002110