Sentrin-specific protease

<StructureSection load='2iy0' size='350' side='right' caption='Structure of human Senp1 catalytic domain complex with SUMO1 and RanGAP C terminal (PDB entry 2iy0)' scene=>

Sentrin-specific protease 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide.

3D structures of sentrin-specific protease3D structures of sentrin-specific protease

Senp1

2ckg, 2iyc – hSenp1 C terminal – human
2xph, 2xre – hSenp1 C terminal + Co
2ckh, 2iyd – hSenp1 C terminal + SUMO2
2iy1, 2g4d – hSenp1 C terminal (mutant) + SUMO1
2iy0 – hSenp1 C terminal + SUMO1 + RanGAP C terminal

Senp2

1tgz – hSenp2 catalytic domain + SUMO1
1th0 – hSenp2 catalytic domain
2io0 – hSenp2 catalytic domain (mutant) + SUMO1 precursor
2io1 – hSenp2 catalytic domain (mutant) + SUMO3 precursor
2io3 – hSenp2 catalytic domain (mutant) + SUMO2 + RanGAP C terminal
2io2 – hSenp2 catalytic domain (mutant) + SUMO1 + RanGAP C terminal

Senp7

3eay – hSenp7 catalytic domain + SUMO1

Senp8

1xt9, 2bkr – hSenp8 + Nedd8
2bkq – hSenp8