4jh3

Crystal Structure of FosB from Bacillus cereus with Zinc and FosfomycinCrystal Structure of FosB from Bacillus cereus with Zinc and Fosfomycin

FunctionFunction

[FOSB_BACC1] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).

About this StructureAbout this Structure

4jh3 is a 2 chain structure with sequence from Bacc1. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Thompson MK, Keithly ME, Harp J, Cook PD, Jagessar KL, Sulikowski GA, Armstrong RN. Structural and Chemical Aspects of Resistance to the Antibiotic Fosfomycin Conferred by FosB from Bacillus cereus. Biochemistry. 2013 Sep 30. PMID:24004181 doi:10.1021/bi4009648

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OCA

[1] Thompson MK, Keithly ME, Harp J, Cook PD, Jagessar KL, Sulikowski GA, Armstrong RN. Structural and Chemical Aspects of Resistance to the Antibiotic Fosfomycin Conferred by FosB from Bacillus cereus. Biochemistry. 2013 Sep 30. PMID:24004181 doi:10.1021/bi4009648

[xtra 1]