4fbt
Dpo4 post-insertion complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesionDpo4 post-insertion complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesion
Template:ABSTRACT PUBMED 23876706
FunctionFunction
[DPO4_SULSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]
About this StructureAbout this Structure
4fbt is a 3 chain structure with sequence from Sulso. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Kirouac KN, Basu AK, Ling H. Structural Mechanism of Replication Stalling on a Bulky Amino-Polycyclic Aromatic Hydrocarbon DNA Adduct by a Y Family DNA Polymerase. J Mol Biol. 2013 Jul 20. pii: S0022-2836(13)00454-3. doi:, 10.1016/j.jmb.2013.07.020. PMID:23876706 doi:10.1016/j.jmb.2013.07.020