4ior
Crystal Structure of the first bromodomain of BRD4 in complex with DMSOCrystal Structure of the first bromodomain of BRD4 in complex with DMSO
Template:ABSTRACT PUBMED 24100334
DiseaseDisease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]
FunctionFunction
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this StructureAbout this Structure
4ior is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Lolli G, Battistutta R. Different orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2161-4. doi:, 10.1107/S090744491301994X. Epub 2013 Sep 20. PMID:24100334 doi:http://dx.doi.org/10.1107/S090744491301994X
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0