3d4y

GOLGI MANNOSIDASE II complex with mannoimidazoleGOLGI MANNOSIDASE II complex with mannoimidazole

FunctionFunction

[MAN2_DROME] Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity).

About this StructureAbout this Structure

3d4y is a 1 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Kuntz DA, Tarling CA, Withers SG, Rose DR. Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. Biochemistry. 2008 Sep 23;47(38):10058-68. Epub 2008 Aug 30. PMID:18759458 doi:10.1021/bi8010785

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OCA

[1] Kuntz DA, Tarling CA, Withers SG, Rose DR. Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. Biochemistry. 2008 Sep 23;47(38):10058-68. Epub 2008 Aug 30. PMID:18759458 doi:10.1021/bi8010785

[xtra 1]