Single stranded binding protein

Sandbox Single Stranded DNA-Binding Protein (SSB)Sandbox Single Stranded DNA-Binding Protein (SSB)

Introduction The single stranded DNA binding protein (SSB) of E. coli plays an important role in three aspects of DNA metabolism – namely in replication, repair and recombination. During DNA replication, SSB molecules bind to the newly separated DNA strands, keeping the strands separated by holding them in place so that each strand can serve as a template. Structure The structure of SSB consists of a homotetramer that has a DNA binding domain that binds to a single strand of DNA.

spinqualitylabelsall models Structure of Single Stranded DNA-Binding Protein bound to ssDNA (PDB entry 1eyg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Binding Interactions in the Active SiteBinding Interactions in the Active Site

spinqualitylabelsall models Structure of Single Stranded DNA-Binding Protein bound to ssDNA (PDB entry 1kaw) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

ReferencesReferences

PMID: 2087220