4by9

The structure of the Box CD enzyme reveals regulation of rRNA methylationThe structure of the Box CD enzyme reveals regulation of rRNA methylation

FunctionFunction

[FLPA_PYRFU] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity).[HAMAP-Rule:MF_00351] [RL7A_PYRFU] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, box H/ACA, box C/D and box C'/D' sRNAs (By similarity).

About this StructureAbout this Structure

4by9 is a 18 chain structure with sequence from Pyrococcus furiosus. Full experimental information is available from OCA.

ReferenceReference

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↑ Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T. The structure of the box C/D enzyme reveals regulation of RNA methylation. Nature. 2013 Oct 13. doi: 10.1038/nature12581. PMID:24121435 doi:http://dx.doi.org/10.1038/nature12581

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OCA

[1] Lapinaite A, Simon B, Skjaerven L, Rakwalska-Bange M, Gabel F, Carlomagno T. The structure of the box C/D enzyme reveals regulation of RNA methylation. Nature. 2013 Oct 13. doi: 10.1038/nature12581. PMID:24121435 doi:http://dx.doi.org/10.1038/nature12581

[xtra 1]