4c1q

Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy.

FunctionFunction

[PRDM9_MOUSE] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase.

About this StructureAbout this Structure

4c1q is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J. Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9. Cell Rep. 2013 Oct 2. pii: S2211-1247(13)00476-2. doi:, 10.1016/j.celrep.2013.08.035. PMID:24095733 doi:http://dx.doi.org/10.1016/j.celrep.2013.08.035

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Wu H, Mathioudakis N, Diagouraga B, Dong A, Dombrovski L, Baudat F, Cusack S, de Massy B, Kadlec J. Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9. Cell Rep. 2013 Oct 2. pii: S2211-1247(13)00476-2. doi:, 10.1016/j.celrep.2013.08.035. PMID:24095733 doi:http://dx.doi.org/10.1016/j.celrep.2013.08.035

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