3hot

Crystal structure of the Mos1 mariner paired end complex with MnCrystal structure of the Mos1 mariner paired end complex with Mn

Template:ABSTRACT PUBMED 19766564

FunctionFunction

[MOS1T_DROMA] Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site.

About this StructureAbout this Structure

3hot is a 8 chain structure with sequence from Drosophila mauritiana. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Richardson JM, Colloms SD, Finnegan DJ, Walkinshaw MD. Molecular architecture of the Mos1 paired-end complex: the structural basis of DNA transposition in a eukaryote. Cell. 2009 Sep 18;138(6):1096-108. PMID:19766564 doi:10.1016/j.cell.2009.07.012

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OCA

[1] Richardson JM, Colloms SD, Finnegan DJ, Walkinshaw MD. Molecular architecture of the Mos1 paired-end complex: the structural basis of DNA transposition in a eukaryote. Cell. 2009 Sep 18;138(6):1096-108. PMID:19766564 doi:10.1016/j.cell.2009.07.012

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