Leucine transporter

<StructureSection load='3gwu' size='350' side='right' caption='Structure of leucine transporter complex with leucine, antidepressant and Na+ ion (PDB entry 3gwu)' scene=>

Leucine transporter (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT is the target of many antidepressant and recreational drugs. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer.

3D structures of leucine transporter3D structures of leucine transporter

Updated on 06-October-2013

3gwu, 3gwv, 3gww, 2q6h, 2q72, 2qb4, 2qb4, 2qei – AaLeuT + Leu + Na + antidepressant – Aquifex aeolicus
2qju – AaLeuT (mutant) + Leu + Na + Cl + antidepressant
4hod, 4hmk, 3gjd, 3usp – AaLeuT + Leu + Na + halide
3mpn, 3mpq – AaLeuT (mutant) + Leu + Na + halide
3f3e, 3usg, 3usj, 3usi, 3usk – AaLeuT + Leu + Na
4fxz, 3gjc – AaLeuT (mutant) + Leu + Na
3f48, 3f4j, 3f3a, 3f3c, 3f3d, 3f4i – AaLeuT + amino acid + Na
3qs4, 3qs5, 3qs6, 4fy0, 3tu0, 3usl, 3uso, 3usm – AaLeuT (mutant) + amino acid + Na
3tt1 – AaLeuT (mutant) + Na + antibody
3tt3 – AaLeuT (mutant) + antibody