User:Alice Harmon/Sandbox 5
Pyr/Pyl/RCAR family of ABA receptorsPyr/Pyl/RCAR family of ABA receptors
Pyr/Pyl/RCAR family of ABA receptors
Abscisic acid is a plant hormone that signals water deficit, As shown in the figure, in unstimulated cells SnRK2.6/OST1/SRK2E (K) and a protein phosphatase 2C (P) are in a complex (K-P) in which the kinase is dephosphorylated and inactive[1][2]. The kinase and phosphatase are proposed to be tethered via the C-terminal sequence (dashed line) of the kinase[1][2][3]. When ABA levels in the cytosol rise, ABA binds to an ABA receptor (R)[4][5][6]. The activated receptor (R.ABA) binds to the protein phosphatase (R.ABA-P) and inactivates it. SnRK2.6/OST1/SRK2E, although still tethered to the phosphatase, is now free to be activated by autophosphorylation or phoshorylation by another protein kinase[7][8].
ReferencesReferences
- ↑ 1.0 1.1 Umezawa T, Sugiyama N, Mizoguchi M, Hayashi S, Myouga F, Yamaguchi-Shinozaki K, Ishihama Y, Hirayama T, Shinozaki K. Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17588-93. doi:, 10.1073/pnas.0907095106. Epub 2009 Sep 29. PMID:19805022 doi:10.1073/pnas.0907095106
- ↑ 2.0 2.1 Soon FF, Ng LM, Zhou XE, West GM, Kovach A, Tan MH, Suino-Powell KM, He Y, Xu Y, Chalmers MJ, Brunzelle JS, Zhang H, Yang H, Jiang H, Li J, Yong EL, Cutler S, Zhu JK, Griffin PR, Melcher K, Xu HE. Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science. 2012 Jan 6;335(6064):85-8. Epub 2011 Nov 24. PMID:22116026 doi:10.1126/science.1215106
- ↑ Yoshida R, Umezawa T, Mizoguchi T, Takahashi S, Takahashi F, Shinozaki K. The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis. J Biol Chem. 2006 Feb 24;281(8):5310-8. Epub 2005 Dec 19. PMID:16365038 doi:M509820200
- ↑ Yin P, Fan H, Hao Q, Yuan X, Wu D, Pang Y, Yan C, Li W, Wang J, Yan N. Structural insights into the mechanism of abscisic acid signaling by PYL proteins. Nat Struct Mol Biol. 2009 Dec;16(12):1230-6. Epub 2009 Nov 5. PMID:19893533 doi:10.1038/nsmb.1730
- ↑ Ma Y, Szostkiewicz I, Korte A, Moes D, Yang Y, Christmann A, Grill E. Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science. 2009 May 22;324(5930):1064-8. doi: 10.1126/science.1172408. Epub 2009, Apr 30. PMID:19407143 doi:10.1126/science.1172408
- ↑ Park SY, Fung P, Nishimura N, Jensen DR, Fujii H, Zhao Y, Lumba S, Santiago J, Rodrigues A, Chow TF, Alfred SE, Bonetta D, Finkelstein R, Provart NJ, Desveaux D, Rodriguez PL, McCourt P, Zhu JK, Schroeder JI, Volkman BF, Cutler SR. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009 May 22;324(5930):1068-71. doi: 10.1126/science.1173041. Epub 2009, Apr 30. PMID:19407142 doi:10.1126/science.1173041
- ↑ Boudsocq M, Droillard MJ, Barbier-Brygoo H, Lauriere C. Different phosphorylation mechanisms are involved in the activation of sucrose non-fermenting 1 related protein kinases 2 by osmotic stresses and abscisic acid. Plant Mol Biol. 2007 Mar;63(4):491-503. PMID:17103012 doi:10.1007/s11103-006-9103-1
- ↑ Burza AM, Pekala I, Sikora J, Siedlecki P, Malagocki P, Bucholc M, Koper L, Zielenkiewicz P, Dadlez M, Dobrowolska G. Nicotiana tabacum osmotic stress-activated kinase is regulated by phosphorylation on Ser-154 and Ser-158 in the kinase activation loop. J Biol Chem. 2006 Nov 10;281(45):34299-311. Epub 2006 Sep 15. PMID:16980311 doi:10.1074/jbc.M601977200
See AlsoSee Also
[1] Abscisic Acid in Wikipedia