4mep
Crystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligandCrystal Structure of the first bromodomain of human BRD4 in complex with a 3-chloro-pyridone ligand
DiseaseDisease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]
FunctionFunction
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this StructureAbout this Structure
4mep is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0
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OCACategories:
- Homo sapiens
- Arrowsmith, C H.
- Bountra, C.
- Brown, N.
- Delft, F von.
- Edwards, A M.
- Fedorov, O.
- Felletar, I.
- Filippakopoulos, P.
- Hoelder, S.
- Knapp, S.
- Martin, S.
- Picaud, S.
- SGC, Structural Genomics Consortium.
- Vidler, L R.
- Weigelt, J.
- Brd
- Brd4
- Cap
- Hunk1
- Mcap
- Mitotic chromosome associated protein
- Sgc
- Small molecule inhibitor
- Structural genomics consortium
- Transcription-transcription inhibitor complex