1cvr

Crystal structure of the Arg specific cysteine proteinase gingipain R (RGPB)Crystal structure of the Arg specific cysteine proteinase gingipain R (RGPB)

FunctionFunction

[CPG2_PORGI] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Its proteolytic activity is a major factor in both periodontal tissue destruction and in bacterial host defense mechanisms. Activates complement C3 and C5 (By similarity).

About this StructureAbout this Structure

1cvr is a 1 chain structure with sequence from Porphyromonas gingivalis. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Eichinger A, Beisel HG, Jacob U, Huber R, Medrano FJ, Banbula A, Potempa J, Travis J, Bode W. Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold. EMBO J. 1999 Oct 15;18(20):5453-62. PMID:10523290 doi:10.1093/emboj/18.20.5453

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OCA

[1] Eichinger A, Beisel HG, Jacob U, Huber R, Medrano FJ, Banbula A, Potempa J, Travis J, Bode W. Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold. EMBO J. 1999 Oct 15;18(20):5453-62. PMID:10523290 doi:10.1093/emboj/18.20.5453

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