4mcb
H.influenzae TrmD in complex with N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE
Template:ABSTRACT PUBMED 23981144
FunctionFunction
[TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
About this StructureAbout this Structure
4mcb is a 2 chain structure with sequence from Haemophilus influenzae rd kw20. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET. Selective Inhibitors of Bacterial t-RNA-(NG37) Methyltransferase (TrmD) that Demonstrate Novel Ordering of the Lid Domain. J Med Chem. 2013 Aug 27. PMID:23981144 doi:10.1021/jm400718n