3v0l
Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (2GW)Crystal structure of the Fucosylgalactoside alpha N-acetylgalactosaminyltransferase (GTA, cisAB mutant L266G, G268A) in complex with a novel UDP-Gal derived inhibitor (2GW)
Template:ABSTRACT PUBMED 23836908
FunctionFunction
[BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
About this StructureAbout this Structure
3v0l is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Jorgensen R, Pesnot T, Lee HJ, Palcic MM, Wagner GK. Base-modified donor analogues reveal novel dynamic features of a glycosyltransferase. J Biol Chem. 2013 Jul 8. PMID:23836908 doi:10.1074/jbc.M113.465963