Catalase

Catalase (CAT) catalyzes the conversion of hydrogen peroxide to water and oxygen. CAT contains porphyrin-heme Fe group which reacts with the hydrogen peroxide. CAT containing Mn are called pseudocatalase (PCAT). Catalase-peroxidase (CAT KatG) is a bifunctional enzyme with both catalase and peroxidase activities. CAT KatG cofactor is a heme group. It provides defense against oxidative stress by reducing hydrogen peroxide. Mutations in CAT KatG can cause resistance to the anti-malarial drug isoniazid (INH). Catalase-phenol oxidase (CATPO) is a heme-containing CAT which shows phenol oxidase activity.

3D Structures of catalase3D Structures of catalase

Updated on 26-August-2013

1qqw, 1dgb, 1dgf, 1f4j – hCAT - human

4cat – CAT – Penicillium janthinellum

1iph, 1gge, 1ye9, 4bfi – EcCAT Hpii – Escherichia coli

1u2j, 1u2k – EcCAT Hpi C terminal

1u2l – EcCAT KatG

1cf9, 1qf7, 1gg9, 1ggh, 1ggj, 1ggk, 1p7y, 1p7z, 1p80, 1p81, 1qws, 3p9p, 3p9q, 3p9r, 3p9s, 3pq2, 3pq3, 3pq4, 3pq5, 3pq6, 3pq7, 3pq8, 3ttt, 3ttu, 3ttv, 3ttw, 3ttx, 4enp, 4enq, 4enr, 4ens, 4ent, 4enu, 4env, 4enw - EcCAT Hpii (mutant)

4blc, 1tgu, 1th3, 3nwl – bCAT – Bovine

1a4e – CAT A – yeast

2cag, 1e93, 1m85, 1mqf, 1h7k – PmCAT – Proteus mirabilis

1h6n, 3hb6 - PmCAT (mutant)

1hbz, 1gwe, 1gwf – MlCAT – Micrococcus lysodeikticus

1m7s – CAT CatF – Pseudomonas syringae

1qwl, 2iqf – HpCAT – Helicobacter pylori

1si8 – CAT – Enterococcus Faecalis

1sj2, 2cca – MtCAT – Mycobacterium tuberculosis

2ccd - MtCAT KatG (mutant)

1ub2 – CAT – Synechococcus elongatus

1mwv, 2b2o, 2b2q, 2fxg, 2fxh, 2fxj – BpCAT KatG – Burkholderia pseudomallei

1x7u, 2dv1, 2dv2, 3n3r - BpCAT KatG (mutant)

1itk, 2a9e, 3n3s – CAT – Haloarcula marismortui

1sy7 – NcCAT-1 – Neurospora crassa

3ej6, 3zj4, 3zj5, 4aj9, 4bim – NcCAT-3

2j2m – CAT – Exiguobacterium oxidotolerans

2isa – CAT – Vibrio salmonicida

2xf2 - 2iuf – PjCAT – Penicillium janthinellum

2xq1 – CAT – Pichia angusta
4e37 – CAT – Pseudomonas aeruginosa

Catalase binary complexesCatalase binary complexes

7cat, 8cat – bCAT + NADPH

2cah - PmCAT + NADPH

1gwh - MlCAT + NADPH

3n3o - BpCAT KatG + NAD

1nm0 – PmCAT + formiate

1qwm - HpCAT + formic acid

1dgg – hCAT + CN

1th2 – bCAT + N3

3rgp, 3re8 – bCAT + NO

3rgs – bCAT + NH3

2b2r, 2b2s - BpCAT KatG + O

2iuf – PjCAT + O

3n3n - BpCAT KatG + INH

3n3p - BpCAT KatG + INH + AMP

3n3q - BpCAT KatG + INH

3n3h - BpCAT KatG (mutant) + INH

1dgh – hCAT + amino-triazole

1th4 - bCAT + amino-triazole

1ggf - EcCAT HPII (mutant) + H2O2

Pseudocatalase Mn-containingPseudocatalase Mn-containing

1jku – LpPCAT-Mn – Lactobacillus plantarum

1o9i – LpPCAT-Mn (mutant)

2cwl – TtPCAT-Mn Mn-free – Thermus thermophilus

2v8u - TtPCAT-Mn

2v8t - TtPCAT-Mn + chloride

1jkv - LpPCAT-Mn + N3

Catalase-phenol oxidaseCatalase-phenol oxidase

4aue, 4aul, 4aum, 4aun, 4b2y, 4b31, 4b40, 4b5k - CATPO - Scytalidium thermophilum