Flavodoxin
Flavodoxin (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD). It participates in nitrogen metabolism and reduces N2 to NH3 while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red. NrdI is a FDX which is involved in ribonucleotide reduction. WrbA (Tryptophan Repressor-Binding Protein) is also FDX. In E. coli there are 2 distinct FDX I and II. The images at the left and at the right correspond to one representative FDX structure, i.e. the crystal structure of apo-flavodoxin from Helicobacter pylori (2bmv). The space filling objects are of chloride ion and benzamidine.
3D Structures of Flavodoxin3D Structures of Flavodoxin
Updated on 21-August-2013
Apo FDXApo FDX
2kqu, 1dx9 – AnFDX (mutant) apo – Anabanea – NMR
2bmv – HpFDX apo - Helicobacter pylori
3d7n – FDX apo – Agrobacterium tumefaciens
2rg1 - EcFDX WrbA apo - Escherichia coli
2hna, 2hnb – EcFDX apo – NMR
1qhe, 1ftg – nFDX apo – Nostoc
1bu5 – DvFDX apo+riboflavin - Desulfovibrio vulgaris
FDX containing FMN oxidized (quinone)FDX containing FMN oxidized (quinone)
3f6r, 3f6s, 3kap – DdFDX-ox - Desulfovibrio desulfuricans
4heq - FDX-ox – Desulfovibrio gigas
1ag9 – EcFDX-ox
1flv – nFDX-ox
1xyy, 1j9g, 1c7f, 1akr, 1akt, 1akw – DvFDX-ox (mutant)
2fx2, 3fx2, 4fx2, 5fx2, 1fx1 – DvFDX-ox
1czk, 1czr – SeFDX-ox (mutant) - Synechococcus elongates
1czn – SeFDX-ox I
1ofv – SeFDX-ox II
1czu, 1d03 - SeFDX-ox II
2fdx, 1fld, 1fvx, 2fax, 3nll, 4nll, 4nul, 5nll – CbFDX-ox (mutant) - Clostridium beijerinckii
2fcr – FDX-ox – Chondrus crispus
1fue – HpFDX-ox
4j8p - FDX-ox – Bacterioides uniformis
FDX containing FMNH (semiquinone)FDX containing FMNH (semiquinone)
2x2o, 2x2p – NrdI-sq – Bacillus cereus
3kaq, 3f90 – DdFDX-sq
1xt6, 1wsw, 1xyv, 1akv, 1wsb - DvFDX-sq (mutant)
1czh, 1czl - SeFDX-sq (mutant)
2fox, 5nul– CbFDX-sq
FDX containing FMNH2 (hydroquinone)FDX containing FMNH2 (hydroquinone)
2fz5 – FDX-red – Megasphaera elsdenii – NMR
1c7e, 1aku, 1akq - DvFDX-red (mutant)
1czo - SeFDX-red (mutant)
1d04 – SeFDX-red
1fla, 1fln, 2flv, 2fvx, 5ull, 6nul – CbFDX-red (mutant)
Other FDXOther FDX
3esx, 3esy, 3esz, 2v5u, 2v5v, 1obo, 1obv - AnFDX (mutant)
1rcf, 1flv - AnFDX
2wc1 – FDX – Rhodobacter capsulatus
2w5u – HpFDX+C3 inhibitor 1fue - HpFDX
2kaq – DdFDX
2r97, 2r96 – EcFDX WrbA
1ahn – EcFDX
2q9u – FDX di-iron – Giardia intestinalis
2ark – FDX – Aquifex aeolicus
1yob – FDX II – Azotobacter vinelandii
1j9e, 1f4p, 1i10, 1azl – DvFDX (mutant)
1j8q - DvFDX