3ps9

Crystal structure of MnmC from E. coliCrystal structure of MnmC from E. coli

FunctionFunction

[C6ELC9_ECOBD] Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity).[SAAS:SAAS006076_004_060760][HAMAP-Rule:MF_01102]

About this StructureAbout this Structure

3ps9 is a 1 chain structure with sequence from Escherichia coli bl21. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Kim J, Almo SC. Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. BMC Struct Biol. 2013 Apr 24;13:5. doi: 10.1186/1472-6807-13-5. PMID:23617613 doi:10.1186/1472-6807-13-5

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OCA

[1] Kim J, Almo SC. Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. BMC Struct Biol. 2013 Apr 24;13:5. doi: 10.1186/1472-6807-13-5. PMID:23617613 doi:10.1186/1472-6807-13-5

[xtra 1]