User:Alice Harmon/Sandbox 1

Protein Kinase

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contains two beta strands connected by the glycine rich ATP-binding loop with the motif shown in ball and stick.

contains an that couples the phosphates of ATP indirectly to the helix in subdomain III (yellow).

connects to many parts of the kinase and it's orientation is critical for activity. In the active state its invariant glutamate forms a salt bridge with the invariant lysine of subdomain II.

contains the catalytic loop.

contains the Mg-binding loop with the DFG motif, the activation loop, the P+1 loop, and the APE motif.

contains the APE motif. The glutamate in this motif forms a salt bridge with an arginine in in Subdomain X1, which is critical for forming the stable kinase core.

and bind substrate proteins and forms the kinase core.