4isq
Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin IBinding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
FunctionFunction
[SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
About this StructureAbout this Structure
4isq is a 6 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA.