3vxx

Crystal structure of methyl CpG binding domain of MBD4 in complex with the 5mCG/5mCG sequenceCrystal structure of methyl CpG binding domain of MBD4 in complex with the 5mCG/5mCG sequence

FunctionFunction

[MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.

About this StructureAbout this Structure

3vxx is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Otani J, Arita K, Kato T, Kinoshita M, Kimura H, Suetake I, Tajima S, Ariyoshi M, Shirakawa M. Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4. J Biol Chem. 2013 Mar 1;288(9):6351-62. doi: 10.1074/jbc.M112.431098. Epub 2013, Jan 10. PMID:23316048 doi:10.1074/jbc.M112.431098

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OCA

[1] Otani J, Arita K, Kato T, Kinoshita M, Kimura H, Suetake I, Tajima S, Ariyoshi M, Shirakawa M. Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4. J Biol Chem. 2013 Mar 1;288(9):6351-62. doi: 10.1074/jbc.M112.431098. Epub 2013, Jan 10. PMID:23316048 doi:10.1074/jbc.M112.431098

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