Sulfhydryl oxidase

Template:STRUCTURE 3p0k

Sulfhydryl oxidase (SOX) is a flavin-dependent enzyme which catalyze the formation of disulfide bonds from thiol groups. The reaction involves the reduction of O2 to hydrogen peroxide. Erv1p SOX is involved in the biogenesis of Fe/S clusters. ALR is a SOX augmenter of liver regeneration. QSOX is a quiescin SOX. QSOX contain thioredoxin domain, helix-rich domain and FAD-binding domain Erv/ALR.

3D structures of sulfhydryl oxidase3D structures of sulfhydryl oxidase

Update February 2013

Erv2pErv2p

1jr8, 1jra – ySOX protease-resistant domain – yeast

Erv1Erv1

4e0h – ySOX FAD-binding domain
4e0i – ySOX FAD-binding domain (mutant)

Erv1pErv1p

2hj3 – SOX – Arabidopsis thaliana

ErvErv

3p0k, 3qzy – SOX – Autographa californica nucleopolyhedrovirus

ASFVASFV

3gwl – SOX residues 1-103 – African swine fever virus

QSOX1QSOX1

3lli, 3llk – hSOX-1 residues 286-546 – human
3q6o - hSOX-1 residues 33-272
3t58, 3t59 - mSOX-1 residues 36-550 (mutant) - mouse

ALRALR

3mbg, 3tk0 – hALR residues 81-205
3u2l, 3u2m, 3u5s – hALR (mutant)
3r7c - ALR - rat

FAD-linked SOXFAD-linked SOX

3td7 – SOX (mutant) – Acanthamoeba polyphaga minivirus

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Shai Biran, Alexander Berchansky