2j5y
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CRYSTAL STRUCTURE OF THE GA MODULE FROM F.MAGNA
OverviewOverview
The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.
About this StructureAbout this Structure
2J5Y is a Single protein structure of sequence from Finegoldia magna. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:17575979
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