1h5o

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Template:STRUCTURE 1h5o

Solution structure of Crotamine, a neurotoxin from Crotalus durissus terrificusSolution structure of Crotamine, a neurotoxin from Crotalus durissus terrificus

Template:ABSTRACT PUBMED 12709056

FunctionFunction

[MYXC_CRODU] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.[1] [2]

About this StructureAbout this Structure

1h5o is a 1 chain structure with sequence from Crotalus durissus terrificus. Full experimental information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. Nicastro G, Franzoni L, de Chiara C, Mancin AC, Giglio JR, Spisni A. Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom. Eur J Biochem. 2003 May;270(9):1969-79. PMID:12709056
  1. Laure CJ. [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Feb;356(2):213-5. PMID:1176086
  2. Mancin AC, Soares AM, Andriao-Escarso SH, Faca VM, Greene LJ, Zuccolotto S, Pela IR, Giglio JR. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998 Dec;36(12):1927-37. PMID:9839677

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