4j26
Estrogen Receptor in complex with proline-flanked LXXLL peptidesEstrogen Receptor in complex with proline-flanked LXXLL peptides
Template:ABSTRACT PUBMED 23437920
FunctionFunction
[ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
About this StructureAbout this Structure
4j26 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Fuchs S, Nguyen HD, Phan TT, Burton MF, Nieto L, de Vries-van Leeuwen IJ, Schmidt A, Goodarzifard M, Agten SM, Rose R, Ottmann C, Milroy LG, Brunsveld L. Proline Primed Helix Length as a Modulator of the Nuclear Receptor-Coactivator Interaction. J Am Chem Soc. 2013 Mar 7. PMID:23437920 doi:10.1021/ja311748r