NAD synthase

Crystal structure of NAD+ synthase complex with Mg+2, ATP and deamino-NAD 1ee1

NAD+ synthase (NADS) catalyzes the conversion of ATP, deamino-NAD+ and NH3 to AMP, NAD+ and diphophate (PP). NADS is part of the NAD synthesis pathway.

3D Structures of NAD+ synthase3D Structures of NAD+ synthase

Updated on 04-July-2013

3p52 – NADS – Campylobacter jejuni
3q4g – NADS (mutant) – Vibrio cholerae
1wxf – EcNADS – Escherichia coli
1xnh – HpNADS - Helicobacter pylori
2pzb – BaNADS - Bacillus anthracis
3dpi – NADS – Burkholderia pseudomallei

NADS binary complexNADS binary complex

1ifx – BsNADS + deamino-NAD – Bacillus subtilis
1wxh – EcNADS + NAD
3hmq – BsNADS + NAD – Salmonella typhimurium

NADS ternary complexNADS ternary complex

1ih8 – BsNADS + Mg + ATP derivative
1wxe – EcNADS + Mg + AMP
1wxg – EcNADS + Mg + deamino-NAD
2pz8 – BaNADS + Mg + ATP derivative

NADS quaternary complexNADS quaternary complex

1ee1 – BsNADS + Mg + ATP + deamino-NAD
1fyd – BsNADS + Mg + AMP + PP
1kqp – BsNADS + Mg + PP + NAD derivative
1wxi – EcNADS + Mg + AMP + PP
1xng – HpNADS + Mg + ATP + deamino-NAD
2pza – BaNADS + Mg + AMP + PP

1nsy – BsNADS + Mg + ATP + ADP + PP
2nsy – BsNADS + Mg + AMP + NAD + PP

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Michal Harel, Alexander Berchansky, Joel L. Sussman