3zm5
CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITORCRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
Template:ABSTRACT PUBMED 23786712
FunctionFunction
[Q8DNV6_STRR6] Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity).[RuleBase:RU004136]
About this StructureAbout this Structure
3zm5 is a 1 chain structure with sequence from Streptococcus pneumoniae r6. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S. Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem. 2013 May 21;66C:32-45. doi: 10.1016/j.ejmech.2013.05.013. PMID:23786712 doi:10.1016/j.ejmech.2013.05.013
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OCACategories:
- Streptococcus pneumoniae r6
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- Barreteau, H.
- Blanot, D.
- Contreras-Martel, C.
- Dessen, A.
- Gobec, S.
- Hrast, M.
- Knez, D.
- Mengin-Lecreulx, D.
- ONeill, A J.
- Randall, C P.
- Sosic, I.
- Turk, S.
- Adp-forming enzyme
- Atp-binding
- Cell cycle
- Cell divison
- Cell shape
- Cell wall
- Ligase
- Nucleotide-binding
- Peptidoglycan synthesis