1yb1
Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XICrystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
FunctionFunction
[DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
About this StructureAbout this Structure
1yb1 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- 17-beta-estradiol 17-dehydrogenase
- Homo sapiens
- Arrowsmith, C.
- Bray, J.
- Bunkoczi, G.
- Delft, F Von.
- Edwards, A.
- Kavanagh, K.
- Lukacik, P.
- Ng, S.
- Oppermann, U.
- SGC, Structural Genomics Consortium.
- Sundstrom, M.
- Human
- Hydroxysteroid dehydrogenase
- Oxidoreductase
- Sgc
- Short chain dehydrogenase
- Structural genomic
- Structural genomics consortium