4jr5

Structure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) InhibitorsStructure-based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

FunctionFunction

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this StructureAbout this Structure

4jr5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Zheng X, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, Oh A, Wang W, Zak M, Gunzner-Toste J, Zhao G, Yuen PW, Bair KW. Structure-based Identification of Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors. J Med Chem. 2013 Apr 25. PMID:23617784 doi:10.1021/jm400186h

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OCA

[1] Zheng X, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, Oh A, Wang W, Zak M, Gunzner-Toste J, Zhao G, Yuen PW, Bair KW. Structure-based Identification of Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors. J Med Chem. 2013 Apr 25. PMID:23617784 doi:10.1021/jm400186h

[xtra 1]