Macrophage inhibitory factor

<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor complex with inhibitor (PDB entry 2ooh)' scene=>

Macrophage inhibitory factor (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens. MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60.

3D structures of macrophage inhibitory factor3D structures of macrophage inhibitory factor

Updated on 23-June-2013

1mif – MIF (mutant) – rat
1fim, 1gif, 1gd0, 3djh – hMIF – human
1cgq, 1p1g, 4etg, 4eui, 4evg – hMIF (mutant)
1mff – mMIF (mutant) – mouse
1hfo – MIF – Trichinella spiralis
1uiz – MIF – Xenopus laevis

MIF complexesMIF complexes

1mfi, 2gdg – mMIF + inhibitor
1ca7 – hMIF + hydroxyphenylpyruvate
3ijj – hMIF + hydroxyphenylpyruvate + inhibitor
1gcz, 1ljt, 2ooh, 2oow, 2ooz, 3b9s, 3jsf, 3jsg, 3jtu, 3l5p, 3l5r, 3l5s, 3l5t, 3l5u, 3l5v, 3ijg, 4f2k, 3smb, 3smc – hMIF + inhibitor
3dji – hMIF + tylenol
3ce4 – hMIF + PMSF
3hof – hMIF + cafeic acid
3u18 – hMIF + Chicago sky blue