4hl8

Re-refinement of the vault ribonucleoprotein particleRe-refinement of the vault ribonucleoprotein particle

Template:ABSTRACT PUBMED 19150846

FunctionFunction

[MVP_RAT] Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity).

About this StructureAbout this Structure

4hl8 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M, Tsukihara T. The structure of rat liver vault at 3.5 angstrom resolution. Science. 2009 Jan 16;323(5912):384-8. PMID:19150846 doi:http://dx.doi.org/323/5912/384

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OCA

[1] Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M, Tsukihara T. The structure of rat liver vault at 3.5 angstrom resolution. Science. 2009 Jan 16;323(5912):384-8. PMID:19150846 doi:http://dx.doi.org/323/5912/384

[xtra 1]