3k2x
Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with 5'-iodo-cytosineCrystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Burkholderia pseudomallei in complex with 5'-iodo-cytosine
Template:ABSTRACT PUBMED 21359640
FunctionFunction
[ISPF_BURP1] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]
About this StructureAbout this Structure
3k2x is a 3 chain structure with sequence from Burkholderia pseudomallei. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Begley DW, Hartley RC, Davies DR, Edwards TE, Leonard JT, Abendroth J, Burris CA, Bhandari J, Myler PJ, Staker BL, Stewart LJ. Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei. J Struct Funct Genomics. 2011 Jul;12(2):63-76. Epub 2011 Feb 26. PMID:21359640 doi:10.1007/s10969-011-9102-6
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OCACategories:
- 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
- Burkholderia pseudomallei
- SSGCID, Seattle Structural Genomics Center for Infectious Disease.
- Fbdd
- Fragment crystallography
- Fragment-based drug design
- Fragments of life
- Isoprene biosynthesis
- Lyase
- Metal-binding
- Niaid
- Seattle structural genomics center for infectious disease
- Ssgcid